Safety and Toxicity of Small Molecule Inhibitors in Dogs with Spontaneously Occurring Malignancies — The Use of Real World Data

The VCS Virtual Conference was held from October 15 - 17, 2020. We had the honor of presenting our abstract during the event.

Safety and Toxicity of Small Molecule Inhibitors in Dogs with Spontaneously Occurring Malignancies — The Use of Real World Data

The VCS Virtual Conference was held from October 15 - 17, 2020. We had the honor of presenting our abstract during the event.

At FidoCure®, we have created a platform which integrates diagnostic testing and the sequencing of canine tumor DNA, with access to targeted therapy using small molecule inhibitors.

This has enabled us to collect outcome data to complete the “circle of information.”

In brief the poster covered:

  • Therapies have been evaluated in over 400 tumor-bearing dogs
  • The adverse event profile is similar to Palladia ®
  • The most common adverse events are hyporexia diarrhea, anemia and neutropenia
  • There are a few conclusions to this study.

    First, that real world data, data from the medical records of dogs, can be used to assess the tolerability and safety of therapeutics.

    Second, the majority of the small molecule inhibitors that we evaluated had a safety profile that was comparable to those reported for Palladia. We are currently enhancing our platform to capture both clinical and clinicopathologic AEs according to the VCOG-CTCAE criteria.

    In addition, FidoCure® has partnered with CSU for a study evaluating the efficacy of targeted therapies selected by FidoCure on cell lines from 10 types of canine cancers. This information will help inform the most effective dosages and identify potential biomarkers that make certain cancers more responsive to these drugs.

    We would like to send a heartfelt thank you to the Veterinary Cancer Society, all of the veterinary oncologists, and team members who made this study possible.

    Dr. Gerry Post

    Dr. Gerry Post has been practicing veterinary medicine for over 25 years specializing in veterinary oncology. He currently serves as Chief Veterinary Officer at the One Health Company.

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